The game is also geared more towards large amounts of infantry, which works hand in hand with the ability to select a larger squad of troops. The game also builds on a more massive scale battle system. Assault Squad is instead geared more towards massive scale multiplayer battles, and is the first in the series to be based mainly on multiplayer.

Men of War: Assault Squad was the first game in the Men of War series to not have a story-based campaign. Also included were four factions ( Germany, the UK, America and the Soviet Union), which eventually was increased to five with the introduction of Japan in a patch (only in multiplayer). The multiplayer expanded beyond the standard of Faces of War, with a larger number of maps of bigger size. Larger battles usually require the player to eventually assault the enemy rather than defend, if the latter had been given. Other single-player missions require the player to control larger forces in defense of an area, although even those missions provide the player with an outnumbered force. Part of the single-player game reverts to the Soldiers: Heroes of World War II style of battles, with control of a small squad being put in the hands of the player against a larger enemy.

The game includes enhanced graphics compared to Faces of War, and a more expansive single and multiplayer. At the time of release, it had the largest single-player campaign. Men of War was the first to be put under the Men of War name.

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